About 20% to 80% of women develop fibroids by the age of 50.   Globally in 2013 it was estimated that 171 million women were affected.  They are typically found during the middle and later reproductive years.  After menopause they usually decrease in size.  Surgery to remove uterine fibroids occurs more frequently in women in "higher social classes".  Adolescents develop unterine fibroids much less frequently than older women.  Up to 50% of women with uterine fibroids have no symptoms. The prevalence of uterine fibroids among teenagers is %. 
This gene encodes a member of the aldo/keto reductase superfamily , which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. 
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