17beta hydroxysteroid dehydrogenase type 1

About 20% to 80% of women develop fibroids by the age of 50. [11] [1] Globally in 2013 it was estimated that 171 million women were affected. [4] They are typically found during the middle and later reproductive years. [1] After menopause they usually decrease in size. [1] Surgery to remove uterine fibroids occurs more frequently in women in "higher social classes". [11] Adolescents develop unterine fibroids much less frequently than older women. [6] Up to 50% of women with uterine fibroids have no symptoms. The prevalence of uterine fibroids among teenagers is %. [6]

This gene encodes a member of the aldo/keto reductase superfamily , which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [7]

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17beta hydroxysteroid dehydrogenase type 1

17beta hydroxysteroid dehydrogenase type 1

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