Bupleurum is rich in a particular type of saikosapnin that closely resemble the structure of sterols. Therefore bupleurum is a potent anti-inflammatory agent that is used to relieve fevers, inflammation, depression, stagnant liver qi and to raise the yang Qi. This latter effect is attributed to bupleurum's effect on the adrenal gland. Because of this ability to raise yang qi, a percentage of patients who take bupleurum formulas may experience uncharacteristic irritability and anger. If this occurs, one should discontinue the use of the formula containing bupleurum for three days and then gradually resume with a significantly lower dose.
Corticosteroids can produce reversible hypothalamic- pituitary adrenal (HPA) axis suppression with the potential for corticosteroid insufficiency after withdrawal of treatment. Adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for up to 12 months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. If the patient is receiving steroids already, dosage may have to be increased.
A company in China was marketing a brand of skin cream that was widely used to treat eczema in babies. The ingredients consisted of 25 all-natural products, which is a relief until you consider that, in this case, the ingredients list was apparently just 25 words someone pulled out of their ass. The cream was actually laced with a steroid hormone that's extremely dangerous, especially for children, called clobetasol propionate . It's also used for skin conditions, except it shouldn't be used for prolonged periods, shouldn't be used by children, and generally needs a doctor's recommendation. How come? Because using it can cause things like excessive hair growth in women and, in children, Cushing's syndrome, which is characterized by a big, swollen, moon-shaped face, emotional instability, acne, muscle weakening, hair loss, truncal obesity, and buffalo hump. For fuck's sake, buffalo hump! That's not even one of my hilarious pretend things I toss into lists, it's a real thing! Called buffalo hump!