Dermatosis is a condition wherein the skin dermis, hair, nail, etc has an irritation or an anomaly. Corticosteroids are usually used to treat inflammation, but it is observed that corticosteroids sometimes also helped alleviate dermatoses. Corticosteroids, besides their inflammation control action are useful in treating disorders that are caused by hyperactivity of the immune response. Corticosteroids' has side effects, such as allergic responses. Corticosteroids are to be used as a topical ointment only in skin regions with inflammation. Globally, development of new technology, rise in the demand for corticosteroid-responsive dermatoses, and increasing government initiative are the prime growth drivers of global corticosteroid-responsive dermatoses market. In addition, increase in adoption of corticosteroid-responsive dermatoses, and emerging economies such as China, India and others, will create new opportunities for global corticosteroid-responsive dermatoses market. However, higher cost of research and development, and harmful side effects are the key restraints for global corticosteroid-responsive dermatoses market.
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The exact etiopathogenesis of SRMA is unknown ( Tipold 2000 ). Activated T cells have been demonstrated in dogs with SRMA, indicating potential contact with an antigenic stimulus; however, no bacterial or viral agents have been identified to date ( Tipold and others 1996 ). A Th2-mediated immune response is most likely, based on the presence of high CD4:CD8a ratios and a high proportion of B cells in peripheral blood and CSF. A Th2-mediated immune response is further supported by the expression of low levels of Th1-response-related cytokines (IL-2, IFN-γ) and upregulation of Th2 cytokines (IL-4) in blood and CSF in dogs with the acute form of SRMA ( Schwartz and others in press ). This Th2-mediated immune response leads to an upregulation of the humoral immune response and excessive IgA production ( Schwartz and others 2008b ).