Farmakokinetik dan farmakodinamik obat kortikosteroid

Paracetamol is widely used as an analgesic and antipyretic agent in the treatment of pain and fever. Paracetamol has interactions with carbohydrates and alcohols. Durian is the fruit of Indonesia, which contains carbohydrates and alcohols. The purpose of this study was to study the effect of durian juice on the absorption and elimination of paracetamol kinetics and to know the dose of durian fruit juice that affects the absorption and elimination of paracetamol kinetics. The study was conducted using 16 rats, divided into 4 groups (n = 4 per group). Each group was treated as follows: controlparacetamol (paracetamol 9 mg / 200 gBW), dose group 1 (paracetamol 9 mg / 200 gBWand g / 200 gBW durian fruit juice), dose 2 (paracetamol 9 mg / 200 gBW and 1,350 g / 200 gBW of durian fruit juice) and dose group 3 (paracetamol 9 mg / 200gBW and g / 200 gBW durian fruit juice). Blood sampling was performed from the vein of the rat tail at 10, 20, 30, 40, 60, 90, 120, 180, 240, 300 and 360. The amount of paracetamol in plasma was determined by UV spectrophotometer at 243 nm. The results showed that durian fruit juice changed the kinetics of paracetamol uptake, fruit durian juice decreased Ka

Farmakokinetik dan farmakodinamik obat kortikosteroid

farmakokinetik dan farmakodinamik obat kortikosteroid

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