Strength testing should be performed in an attempt to isolate the different components of the rotator cuff to assess weakness. The ‘lift-off’ test (Figure ) can help to assess subscapularis integrity. 28 Although clinically useful, placing the arm in the testing position can be provocative and difficult to achieve, especially in the older population. The ‘belly-press’ test (Figure ) can also help determine integrity of the subscapularis. 29 Resisted external rotation with the elbow by the side is useful in detecting tears extending into the infraspinatus (Figure ). Jobe’s test (Figure ) is most useful in isolating the integrity of supraspinatus. 30 A recent study suggested that if a patient was older than 60 years and had a positive Neer or Hawkins–Kennedy impingement test with weakness in abduction (positive Jobe’s), there was a 98% chance that the patient had a full-thickness rotator cuff tear. 27
There has been massive use of antibiotics in animal husbandry . The most abundant use of antimicrobials worldwide are in livestock; they are typically distributed in animal feed or water for purposes such as disease prevention and growth promotion.  Debates have arisen surrounding the extent of the impact of these antibiotics, particularly antimicrobial growth promoters, on human antibiotic resistance. Although some sources assert that there remains a lack of knowledge on which antibiotic use generates the most risk to humans,  policies and regulations have been placed to limit any harmful effects.
The first sulfonamide and the first systemically active antibacterial drug, Prontosil , was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany,    for which Domagk received the 1939 Nobel Prize in Physiology or Medicine.  Sulfanilamide, the active drug of Prontosil, was not patentable as it had already been in use in the dye industry for some years.  Prontosil had a relatively broad effect against Gram-positive cocci , but not against enterobacteria . Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.