Corticosteroid use can cause a variety of psychiatric syndromes, including mania, psychosis, depression, and delirium. A meta-analysis reports severe psychotic reactions in % of patients taking corticosteroids and mild-to-moderate reactions in 28% of patients. 1 Hypomania, mania, and psychosis are the most common psychiatric reactions to acute corticosteroid therapy. 2 This article reviews case reports and open-label trials of antipsychotics, mood stabilizers, and anticonvulsants to treat corticosteroid-induced mania and psychosis and outlines treatment options.
If you are going to start your first cycle soon, 'how to inject' is probably that last thing that you are worried about. You would have started by conducting research on the different injectable anabolic steroids available in the market, whichyou think can help you reach your goal. But when you have the vials and the syringes in front of you, you will surely think about how you will get the steroid out from the bottle and into your body. At this point, some people will become exasperated and even give up. Here is some information on injecting anabolic steroids.
An intracellular signaling molecule with protein kinase activity known as Akt1 (a major isoform of Akt) [ 6 ] may play a central role in the atrophic and hypertrophic responses of muscle to glucocorticoids and IGF-I, respectively [ 7,8 ]. Glucocorticoid-induced suppression of Akt1 ultimately results in increased amounts of the ubiquitin-ligase atrogin-1 (MAFbx) that targets muscle proteins for degradation [ 7,9 ]. Conversely, IGF-I signaling leads to enhanced activity of Akt1 that suppresses muscle atrophy and that induces muscle hypertrophy [ 8 ].