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Zycortal® (Dechra Veterinary Products) is indicated for replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism.  Zycortal contains desoxycortone pivalate (DOCP) – an aldosterone analogue with purely mineralocorticoid effect.  Zycortal is available as a prolonged-release suspension for subcutaneous injection and the dosing interval is approximately 25 days.  The exact dose to be given and the interval between treatments depend on the dog’s clinical response as well as sodium and potassium levels.  A glucocorticoid (. prednisolone) is also needed daily to replace the missing cortisol.  To obtain a Monitoring and Dose Adjustment Flowchart, or for further advice, contact Dechra by e-mailing technical@.

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